To mark World Tuberculosis Day (24 March), Frontiers presents a selection of articles on the latest research, concepts and innovations in the field of TB.
Frontiers in Microbiology
(Keith D. Green and Sylvie Garneau-Tsodikova)
Many strains of Mycobacterium tuberculosis are becoming increasingly drug-resistant. A mini-review covers how different M. tuberculosis strains resist anti-tuberculosis drugs and how these resistance mechanisms can be overcome.
Frontiers in Cellular and Infection Microbiology
(Antonio Campos-Neto, Mark Cayabyab and Lilia Macovei)
There is currently no vaccine available to protect adults against M. tuberculosis. This review focuses on the current strategies and innovations being explored to create an effective tuberculosis vaccine.
Frontiers in Microbiology
(Iona Bartek, Martin I Voskuil, Gary K. Schoolnik and Kevin Visconti)
This paper studies how M. tuberculosis responds to a number of damaging highly reactive oxygen and nitrogen species, one of the body’s primary defenses against M. tuberculosis infection.
Frontiers in Microbiology
(Reuben J Peters, Francis M Mann, Meimei Xu and Emily K Davenport)
This article attempts to understand the function of two M. tuberculosis genes, Rv3382c and Rv3383c, both believed to be important in human infection.
Frontiers in Cellular and Infection Microbiology
(Shumaila N. M. Hanif and Lucila Garcia-Contreras)
Pharmaceutical aerosols are usually used to treat conditions such as asthma. This review examines how they could be used to treat tuberculosis by delivering drugs and vaccines directly into the lungs.
Frontiers in Physiology
(Mohammad Fallahi-Sichani, Denise E. Kirschner and Jennifer J. Linderman)
The human NF-κB signaling pathway is central to the body’s defensive response against many bacterial and viral attacks. This paper explores a mathematical model that studies how the NF-κB pathway reacts to M. tuberculosis infection.
Frontiers in Microbiology (Research Topic)
(Topic editor: Adel M Talaat)
M. tuberculosis is closely related to another bacteria, Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis), which infects cattle. This Research Topic brings together a collection of special papers to cover the advances in the understanding of both diseases.